3) VAPB and PTPIP51 have been identified as ER-mitochondria tethers that are disrupted in FTD/ALS (Stoica et al., 2014; Bernard-Marissal et al., 2015; Dafinca et al., 2016; Gregianin et al., 2016; Stoica et al., 2016; Watanabe et al., 2016; Dafinca et al., 2020; Gomez-Suaga et al., 2022). This evidence concerns the gene RMDN3 and frontotemporal dementia.