The tethering proteins most strongly linked to FTD/ALS involve an interaction between the integral ER protein vesicle-associated membrane protein-associated protein B (VAPB) and the outer mitochondrial membrane protein, protein tyrosine phosphatase interacting protein-51 (PTPIP51) (De Vos et al., 2012; Stoica et al., 2014). This evidence concerns the gene RMDN3 and frontotemporal dementia.