In conclusion, by integrating WGCNA and differential gene expression analysis, our study screened five important survival-related genes (SLC26A3, GUCA2A, CLCA4, CLCA1, and AQP8) and a 3-gene risk model with the potential to predict the prognosis of colorectal adenocarcinoma. Here, GUCA2A is linked to colorectal adenocarcinoma.