THBS1 and glaucoma: The reader is referred to several excellent reviews covering broader roles of TSP-1 and other matricellular proteins in glaucoma and in fibrotic ECM remodeling for a more extensive discussion (Rhee et al., 2009; Chatterjee et al., 2014; Wallace et al., 2014; Murphy-Ullrich and Downs, 2015; Murphy-Ullrich, 2019; Keller and Peters, 2022).