MYOC and glaucoma: In a fraction of glaucoma cases in which patients express myocilin with mutations that affect protein folding, aggregation, and retention in the ER [juvenile open-angle, ∼4% of adult onset primary open-angle (Kwon et al., 2009)], mutant myocilin engages pro-glaucoma alterations in cell adhesion and signaling and autophagy (Stone et al., 1997; Liu and Vollrath, 2004; Yan et al., 2020; Sharma and Grover, 2021).