TNFSF11 and Fabry disease: A recent study showed that RANKL is involved in the pathophysiology of fibrous dysplasia of bone (FD), a genetic disease affecting the skeleton where postnatal skeletal stem cells acquire a fibroblastic phenotype and proliferate, replacing bone marrow resident cells and causing bone demineralization, an increase in osteoclast density, and, consequently, the dysregulation of osteoclastogenesis (de Castro et al., 2019).