Of note, this signature was also partially found in other glioma cell lines in response to temozolomide, and TCGA glioblastoma database analysis for KLK5, FAT2, CHI3L1, and HB-EGF expression showed that alteration of these genes impacts Kaplan–Meier estimate of overall survival and disease/progression-free (Rabé et al., 2020). Here, HBEGF is linked to central nervous system cancer.