In addition, these data showed significant differences in PON1, KLRB1, ANXA10, IL15RA, HILPDA, HAVCR1, G6PD, CDCA8, and CBX2 between HCC and normal liver tissues, and this trend was the same as in the model (Supplementary Figure S4). The gene discussed is CBX2; the disease is hepatocellular carcinoma.