Compared with adjacent normal liver tissues, the protein expression levels of genes (PON1, KLRB1, ANXA10) in HCC tissues decreased significantly, while the protein expression levels of IL15RA, HILPDA, HAVCR1, G6PD, CDCA8, and CBX2 in HCC tissues increased. The gene discussed is HAVCR1; the disease is hepatocellular carcinoma.