Therefore, the synergistic interaction between IL-3 and certain alarmins on the release of immunomodulatory cytokines from hBaso and mBaso might be relevant in the pathophysiology of different basophil-mediated disorders such as allergic diseases (27–30), parasitic infections (82, 83), autoimmunity (31–34), and cancer (37–40). Here, IL3 is linked to allergic disease.