A study of 36 patients enrolled in the Infant Immune Study looking for DNA methylation signatures predictive of childhood asthma identified that cord blood mononuclear cells (CBMCs) harbored 589 differentially methylated regions (DMRs) associated with childhood asthma; further analysis of which showed a significant enrichment of DMRs in genes controlled by immunoregulatory TGF-β1 and pro-inflammatory IL-1β (101). The gene discussed is TGFB1; the disease is asthma.