ITM2C and allergic disease: The genes C20orf166, STAC, SYT8, KCNJ15, SCD, LINCOO669, PLEKHA2, ITM2C, NT5C3A and NPEPL1 had the most significant differentially methylated sites of which SCD, ITM2C, NT5C3A and NPEPL1 genes are known to impact the immune system, allergy, and asthma; thereby suggesting that maternal atopy constitutes a unique intrauterine environment which is associated with the induction of distinct methylation patterns associated with the inheritance of a pro-atopic state (99).