AKT1 and immunoglobulin G4-related sclerosing disease: The top enriched GSEA items for the Mem_unsw B cells included “PI3K-Akt signaling pathway”, “Th1 and Th2 cell differentiation,” and “Th17 cell differentiation”, indicating the enhanced proliferation and ability to activate T-cell responses in patients with IgG4-RD (Figure 2F).