EGR1 and immunoglobulin G4-related sclerosing disease: Therefore, further efforts are still needed to validate the phenomenon that we observed at present study, e.g., whether enhanced glycolysis ability promote abnormal B-cell class-switching and antibody production, the role of increased EGR1 expression in monocytes, whether the involved pathways are actually enriched and their role in T/NK cells functions of patients with IgG4-RD.