Another study showed that lower expression of the DNA nuclease MRE11A in the CD4+T cells of patients with RA compared to HCs caused mtDNA oxidation and leakage into the cytosol, inducing activation of the NLRP3 and AIM2 inflammasomes to guide CD4+T cell pyroptosis (147). The gene discussed is NLRP3; the disease is rheumatoid arthritis.