NLRP3 and colitis: Moreover, numerous microRNAs (miRNAs)-related active agents have been shown to ameliorate colitis by abrogating cell pyroptosis, namely human umbilical cord mesenchymal stem cell (hucMSC)-derived exosomal miR-378a-5p, which inhibits NLRP3 inflammasome assembly (164), and Roseburia intestinalis-derived flagellin via blocking the miR-223-3p/NLRP3 axis to decreaseNLRP3 inflammasome activation (165).