For instance, circHIPK3 was proven to modulate the proliferation of airway smooth muscle cells by the miR-326/STIM1 axis in asthma (69), a group of ample circRNAs and ceRNA networks were found to likely contribute to acquired immune deficiency syndrome (AIDS) (70), and a two-circular RNA signature of donors was thought to be a biomarker of early allograft dysfunction after liver transplantation (71). Here, STIM1 is linked to AIDS.