In accordance with this, in a MC903-induced AD model, basophil depletion decreased the expression of IL-4 and IL-13 in skin lesion, reduced epidermal hyperplasia and keratinocyte proliferation and significantly reduced trans-epidermal water loss (67), indicating the involvement of basophils in skin barrier dysfunction through the IL-4 and IL-13 production. The gene discussed is IL4; the disease is Alzheimer disease.