The fact that 13.2% of significant CRP-QTLs that were identified previously in a large cohort of healthy individuals could be replicated in a small patient cohort and the significant enrichment of CRP-QTLs in appendicitis GWAS suggests the causal role of CRP in the disease and bridge a knowledge gap regarding SNP–disease associations in appendicitis. The gene discussed is CRP; the disease is appendicitis.