Serum levels of galectin-1, galectin-9, CXCL10 (C-X-C motif chemokine 10 precursor) and TNFRII (TNF receptor superfamily member 1B) proteins correlated with severity of disease activity in treatment-naïve JDM patients (46). The gene discussed is TNFRSF1B; the disease is juvenile dermatomyositis.