HLA-DQB1 and diabetes mellitus: Individuals with anti-TIF1 autoantibodies were associated with HLA-DQB1. However, haplotypic associations differed with age of onset, with the strongest associations to HLA-DQB1*02:01 (8.1 ancestral haplotype) and HLA-DQB1*02:02 in juvenile- and adult-onset DM respectively (18).