WDFY4 and clinically amyopathic dermatomyositis: However, this study identified genome-wide significant association to a variant of the WDFY4 (WDFY family member 4) gene in CADM [OR (95% CI) 3.87 (2.23-6.55)], with nominal association of neighbouring WDFY4 variants in 21 adults with CADM of European ancestry.