Accumulating evidence has shown that RIG-I participates in cellular damage and the occurrence and development of many diseases, such as acute myeloid leukemia (AML), hepatocellular carcinoma, lupus nephritis, immunoglobulin A nephropathy, Crohn’s disease, rheumatoid arthritis, and cardiovascular diseases (CVD) (12–18). This evidence concerns the gene RIGI and Crohn disease.