The main mechanism is to increase the expression of SIRT1 through sponge miR-326/miR-487a-3p/SIRT1, reduce the toxicity of high glucose on renal tubular epithelial cells, inhibit the proliferation of renal tubular epithelial cells, reduce the secretion of inflammatory cytokines and delay the progression of diabetic nephropathy. Here, SIRT1 is linked to diabetic kidney disease.