In Beroukhim's dataset, the mRNA levels of PSMB8, PSMB9 and PSMB10 were higher in non-hereditary ccRCC with a fold change of 4.678, 5.890 and 3.808, in hereditary ccRCC with a fold change of 5.235, 6.592 and 5.009, respectively, PSMB8 was overexpressed in ccRCC with a fold change of 15.139 38. The gene discussed is PSMB10; the disease is nonpapillary renal cell carcinoma.