The presented report shows that 1,25(OH)2D3 induces a significant reduction of IL-17A production from PBMCs both in SSc and in healthy subjects, in a dose dependent manner, accordingly with other previously published data demonstrating that 1,25(OH)2D3 has an inhibitory effect on Th17 cells and reduces the expression of IL17 both in SSc and in other autoimmune diseases 13, 45-49. The gene discussed is IL17A; the disease is autoimmune disease.