In SSc derived PBMCs, treatment with 1,25(OH)2D3 induced a significant reduction of FGF2 synthesis compared to untreated cells in a dose-dependent manner (10-9M 13.09±4.4; 10-8M 12.36±4.06; 10-7M 10.87±3.53 vs 15.76±5.18 pg/ml in untreated cells) (Figure 2). This evidence concerns the gene FGF2 and systemic sclerosis.