Patients with ILD showed higher levels of TGFβ, FGF2 and CTGF in comparison to patients without ILD (866.2±253.6 vs 705.1±199.6 pg/ml p=0.015; 18.5±4.7 vs 13±4.1 pg/ml p=0.0001; 111.2±13 vs 99.3±12.8 pg/ml, p=0.002 respectively), same as patients with DU (847.9±236 vs 667.1±204 pg/ml p=0,009; 17.6±4.3 vs 12.3±4.8 pg/ml, p=0.0001; 108.2±13.6 vs 99.6±13.6 pg/ml, p=0,036 respectively). Here, CCN2 is linked to interstitial lung disease.