Furthermore, 57 pairs of ccRCC tissues were subjected to immunohistochemical (IHC) staining and representative pictures were shown in Figure 2E. Consistent with the western blot results, IHC result showed that both C1QBP and XDH were down-regulated in ccRCC tissues, and further statistical correlation analysis revealed that C1QBP positively correlated with XDH (r = 0.552, P < 0.001) (Table 5). Here, C1QBP is linked to nonpapillary renal cell carcinoma.