In mammalian cell membranes, interactions between sphingomyelin and Chol drive the formation of membrane rafts; heterogeneous, dynamic membrane nanodomains that serve as functional platforms that regulate various cellular processes (e.g., immune signalling, host-pathogen interactions, development and regulation of cardiovascular disease and cancer) as a result of the segregation of specific lipid-anchored proteins within raft domains (Pike, 2006; Michel and Bakovic, 2007; Lingwood and Simons 2010; Sezgin et al., 2012). Here, PROS1 is linked to cancer.