Compared to the CNIs, the mTOR inhibitors have been postulated as having significant anti-neoplastic, anti-angiogenetic and anti-proliferative properties, related to the selective inhibition of protein synthesis required for cancer cell growth and proliferation, with the induction of G1 cell cycle arrest, promoting cancer cell apoptosis, decreased translation of DNA damage, as well as restoration of radiosensitivity in some radioresistant tumors[81,82]. Here, MTOR is linked to cancer.