ABCA7 and Alzheimer disease: Previous genome-wide association studies (GWASs) have found and defined up to 20 AD susceptibility loci, including ABCA7, BIN1, CLU, CR1, PICALM, SORL1, and so on (Harold et al., 2009; Lambert et al., 2009, 2013; Steinberg et al., 2015; Vardarajan et al., 2015; Giri et al., 2016; Kunkle et al., 2019).