APOE and Alzheimer disease: Among APOE ε4 carriers, the allele and genotype frequencies of ABCA7 rs3764650 were substantially different between AD and control cases [allele: P = 0.030, odds ratio (OR) = 1.80, 95% confidence interval (CI) 1.05–3.06, genotype: P = 0.034], and allele G was higher in the AD group than that in the control group (Table 2A).