The results revealed that rs3764650 of ABCA7 was correlated with the AD morbidity in the allele model (P = 0.010, OR = 1.43, 95% CI 1.09–1.89) without adjusting the age and gender, dominant (P = 0.004, OR = 1.71, 95% CI 1.19–2.46), and additive (P = 0.012, OR = 1.42, 95% CI 1.08–1.86) models after adjusting the age and gender. Here, ABCA7 is linked to Alzheimer disease.