Moreover, among APOE ε4 carriers, the allele and genotype frequencies of ABCA7 rs4147929 showed the obvious difference between patients with AD and healthy controls (allele: P = 0.001, OR = 2.49, 95% CI 1.42–4.37, genotype: P = 0.003), with allele A higher in the case group than that in the control group (Table 2B). This evidence concerns the gene APOE and Alzheimer disease.