In another study, an elevated level of C-reactive protein (CRP), a non-specific marker for inflammation, was found in the cerebrospinal fluid (CSF) and serum from patients with mild cognitive impairment (MCI) (Schuitemaker et al., 2009), which is considered as an early stage of AD and other dementia (Petersen, 2011). This evidence concerns the gene CRP and Alzheimer disease.