It is generally accepted that the deposition of β-amyloid (Aβ) plaques and neurofibrillary tangles (NFTs) caused by Aβ aggregation and hyperphosphorylated tau protein, respectively, are the primary events that lead to progressive loss of cognitive function in AD patients (Brunden et al., 2009; Busche and Hyman, 2020; Walsh and Selkoe, 2020). This evidence concerns the gene MAPT and Alzheimer disease.