Interestingly, genetic ablation of NLRP3 or Caspase-1 significantly reduced Aβ deposition in APP/PS-1 mouse model of AD which was largely due to the enhanced phagocytic capacity in NLRP3-/Caspase-1-deficient microglia to actively engulfing Aβ plaques. This evidence concerns the gene NLRP3 and Alzheimer disease.