TREM2 and Alzheimer disease: Further study revealed that AD Mice with TREM2 haplodeficiency or TREM2-deletion led to the formation of more diffused Aβ plaques, which increased the area of contact between Aβ plaques and adjacent neurons resulting in exaggerated axonal damages in the surrounding tissues (Yuan et al., 2016b; Meilandt et al., 2020).