MAPT and Alzheimer disease: Aβ-induced activation of NLRP3 inflammasome led to the formation of apoptosis-associated spec-like protein containing a CARD (ASC) proteins, resulting in augmented neuroinflammatory responses (Baroja-Mazo et al., 2014; Franklin et al., 2014) and enhanced tau pathology associated with the progressive loss of cognitive function in AD patients (Ising et al., 2019).