The aim of this study was to examine the association between the activity of cholinergic enzymes and CSF markers reflecting the state of brain amyloidosis (Aβ42), neurodegeneration (T-tau, NFL), neurofibrillary tangles (P-tau) and inflammation (YKL-40, S100B, GFAP) among subjects at the pre-and early symptomatic stages of dementia. This evidence concerns the gene MAPT and dementia.