When the organism is infected with pneumonia, mycoplasma enters the lung through the airway and stimulates macrophages at the alveoli, producing inflammatory cytokines such as CRP and IL-6, and then stimulates various cytokines in the lungs and induces inflammatory cells in the peripheral circulation to enter the alveoli and interstitium, which in turn produce a large number of cytokines and inflammatory mediators, further aggravating the inflammatory response of the organism (22). The gene discussed is CRP; the disease is pneumonia.