Consequently, on day 21 after tumor cell inoculation, the tumor volume of 4T1-CXCL13-2 in CD4+ T lymphocyte depletion mice showed similar shrinkage and regression as in previous BALB/c mice experiment, whereas CXCL13-mediated tumor inhibition was almost completely abolished after CD8+ T lymphocyte depletion. The gene discussed is CD8A; the disease is neoplasm.