Moreover, we observed significantly lower microvessel density in CXCL13-overexpressing 4T1 tumor, and this was supported by one previous study that CXCL13 modulated angiogenesis by inhibiting fibroblast growth factor 2-induced chemotaxis, proliferation, and survival of endothelial cells.45 The gene discussed is CXCL13; the disease is neoplasm.