Immune cell infiltration in TNBC has been considered to be correlated with a favorable clinical outcome.30 Meanwhile, high-expressing CXCL13 tumors have also been identified with a higher TIL density.11,31 Furthermore, after transfection with the transcription factor of CXCL13, human breast cancer MDA-MB-231 showed special recruitment to healthy donor-derived CXCR5 + T and B cells.23 Therefore, CXCR5 + immune cells can probably respond to the chemotaxis signal of CXCL13, migrate to tumor microenvironment, and elicit antitumor immune response. This evidence concerns the gene CXCR5 and breast carcinoma.