For instance, CXCL9 and CXCL10 secretions by Ewing sarcoma chemoattracted a large number of CD8+ cytotoxic T lymphocytes and were negatively correlated with tumor progression.28 In the current study, we found that the intratumoral CXCL13 expression could mediate significant in vivo growth inhibition in mouse 4T1 breast cancer, and 4T1-CXCL13 tumors started to shrink and were even completely eliminated at ∼3 weeks after inoculation. This evidence concerns the gene CD8A and Ewing sarcoma.