CSF1R and Nasu-Hakola disease: In this context, deficits in colony-stimulating factor 1 receptor (CSF1R) or TREM2 are correlated with a rare group of neurodegenerative disorder, for example, adult-onset leukoencephalopathy with axonal spheroids (i.e., characterized by excessive demyelinating lesions in the cerebral white matter) or Nasu-Hakola disease (i.e., characterized by multiple bone cysts linked to neurodegeneration), respectively [198–200].