In addition, Runt-related transcription factor 1 (RUNX-1), Sal-like 1 (SALL-1), T-cell-acute-lymphocytic leukemia protein-1 (TAL-1), and interferon regulatory factor 8 (IRF8) genes acquainted with microglia maturation and ramification are also influenced by AD pathology [60]. This evidence concerns the gene IRF8 and Alzheimer disease.