ITGB8 and cancer: A GWAS study identified 21 new loci, three of them were located within 150 kb of integrin gene (ITGA4, ITGAV, and ITGB8) cluster, and one overlapped with a fourth integrin gene, ITGAL. Integrins are bidirectional signaling cell adhesion mediators that play an essential role in leukocyte homing and cell differentiation in inflammation and cancer.