In this study, first, by comparing the mRNA and protein quantification of EMT and Shh-related factors in the livers of patients with BA and normal controls, the results confirmed that the mRNA and protein expression of GLI2, Snail, vimentin, and α-SMA were almost all higher in the BA group, while E-cadherin was significantly lower, suggesting the existence of EMT and the enhancement of the Shh signaling pathway in BA cirrhosis. The gene discussed is SHH; the disease is Cirrhosis.