The present study was designed to verify the existence of Shh and EMT in hepatic fibrosis of BA by detecting the expression of Shh- and EMT-related factors in BA liver biopsy samples and to investigate the relationship between the two and the specific regulatory mode of regulatory factors involved in the fibrosis process to find new ideas for the prevention and treatment of liver fibrosis in BA. The gene discussed is SHH; the disease is Hepatic fibrosis.