Cui et al. (32) found significantly lower expression of the GPC1 gene in BECs from children with BA than in normal controls and determined that glypican 1, a heparan sulfate proteoglycan encoded by the GPC1 gene, could regulate Shh signaling, suggesting that the Shh signaling pathway may be important in liver fibrogenesis in BA. Here, CD44 is linked to breast angiosarcoma.