RYR1 and myopathy: In this study, 170 DEGs were identified by comparing genes expressed in skeletal muscle samples from healthy and RYR1 mutation-associated myopathies: as revealed by the GO enrichment analysis of all DEGs, actin filament-based movement, actin-mediated cell contraction, muscle contraction, muscle filament sliding, actin-myosin filament sliding, muscle system process, actin binding, myosin II complex, muscle myosin complex, contractile fiber part, contractile fiber, myofibril, sarcomere, and myosin.