These target genes were found to be enriched in 28 KEGG pathways (EGFR tyrosine kinase inhibitor resistance, cancer-related pathway, epithelial cell signaling in Helicobacter pylori infection, rheumatoid arthritis, endocrine resistance; ErbB, MAPK, PI3K−Akt, Rap1, HIF−1, relaxin, estrogen, GnRH, and AGE−RAGE signaling pathways in diabetic complications; and so on). Here, GNRH1 is linked to rheumatoid arthritis.