These genes and their products have been identified as negative prognostic markers in colon cancer patients.50,51 GLSF down-regulated Nppb, encoding for natriuretic peptide B, which has been shown to be a key oncogene candidate for colon tumors and suggested as one of the early biomarkers for prevention in the clinical setting.52 The gene discussed is NPPB; the disease is colonic neoplasm.