For example, the same mycelia extract mentioned above suppressed the number and size of precancerous colorectal adenomas in human subjects who took the mycelia extract at 1.5 g/day for 12 months.12 In patients with advanced colorectal cancer, taking oral GL at 5.4 g/day for 12 weeks induced some changes in immune-related parameters such as IL-1 and TNF-α, although the effects were not statistically significant.13 Third, GL has shown some antitumor efficacy in a few preclinical studies of human colon cancer cell lines in vitro. The gene discussed is IL1B; the disease is colorectal cancer.