Some of them may be tumor suppressor genes, for example, Fmo2 (flavin containing monooxygenase 2) plays a role as a tumor suppressor in lung cancer.53 The lower level of Inpp5j, which encodes inositol polyphosphate-5-phosphatase J, has been associated with more aggressive tumors and poorer survival of cutaneous squamous cell carcinoma,54 and was found to be deficient in oropharyngeal squamous cell carcinoma.55  Itga10, a top DEG of the GLSF-up-regulated genes, encodes integrin subunit α 10, which binds to collagen and plays a role in cell adhesion and cell-surface mediated signaling. The gene discussed is ITGA10; the disease is cutaneous squamous cell carcinoma.