Besides, different ferroptotic immune cells play different roles in tumor immunity: ferroptosis of anti-tumor immune cells (including CD8 + T cells, NK cells, and DC) leads to low immune function; ferroptosis of suppressive immune cells, such as M2 tumor-associated macrophages and Tregs, reverse their tumor-promoting functions (Talty and Bosenberg, 2021). The gene discussed is CD8A; the disease is neoplasm.