Other studies indicated that ANKH took part in chondrocalcinosis articularis (Kumar et al., 2019), fibroblast ossification (He and Dong, 2020), and vascular smooth muscle cell calcification (Chen et al., 2019a), suggesting that ANKH may play a crucial role in the hardening and remodeling of TM cells in POAG patients. This evidence concerns the gene ANKH and open-angle glaucoma.