SLC6A8 and neoplasm: In recent studies, it was also revealed that SLC6A8-mediated creatine uptake and accumulation reprograms macrophage polarization by modulating cytokine responses such as IFN-g and IL-4, thereby altering macrophage-mediated immune responses in vivo (Ji et al., 2019), which could also be used to modulate the anti-tumor response of CD8 T+ cells by affecting creatine uptake (Di Biase et al., 2019).