Taken together, our research identified compound heterozygous DNAH17 variants (c.4109C>T and c.9776C>T; c.612C>G and c.8764C>T) in families with LR asymmetry disorders, typical phenotypes of ciliary disorders, including SIT, dextrocardia, and CHD, albeit infertility cannot be excluded. The gene discussed is DNAH17; the disease is Dextrocardia.