The HPV positive HNSCC group exhibited a higher CXCL10 mRNA level and an increased methylation of CXCL9 and CXCL11 compared with the HPV negative HNSCC group (Supplementary Figures S7B, S7D; t test, p < 0.05). This evidence concerns the gene CXCL9 and head and neck squamous cell carcinoma.