Further exploration on the crosstalk among the four chemokines, TME, and immune cells in the immune circle by analyzing the relevance in TCGA cohort disclosed that CXCL9, CXCL10, CXCL11, and CCL5 showed a strongly positive association with immune cells (Macrophages M1, CD4 T cells memory activate and CD8 T cells), and the three stages of tumor immune circle (Figure 6F). This evidence concerns the gene CD8A and neoplasm.