The TCGA and most high-graded cohorts showed a higher enrichment of immune cells (Macrophages M1, CD4 T cells memory activated, and CD8 T cell) in the infiltration grading of the 22 kinds of the immune cells, got higher scores in the enrichment of antigen present during tumor immune circle, immune cell infiltration, and the recognizing and killing of tumor cells by effector T cells in the 29 immune signatures assay (Figure 6A), and was given the lower scores in the TIDE assay. Here, CD4 is linked to neoplasm.