The four chemokines were associated positively with Macrophages M1, activated CD4, and CD8 T cells, but negatively with Macrophages M0 (in TCGA HNSCC cohort) and tumor-associated monocyte/macrophages (GEO cohort), suggesting the lower expression of the four chemokines in the early tumor-associated monocyte/macrophages or macrophages M0, and the gradually elevated expression in differentiating TAMM. The gene discussed is CD8A; the disease is neoplasm.