The scRNA-seq data further disclosed that the four chemokines and their receptors were highly expressed in DCs, enhancing the antigen presentation in TME; the high CCL5 expression in CD8 T cells, NK cells, and certain TAM promoted inflammation; the tumor cells highly expressing CXCL9, CXCL10, and CXCL11 attracted the CD8 T cells, NK cells, and TAM, which eliminated tumor cells by perforating cell membrane, digesting through serine proteases and apoptosis via ligand binding (Lee et al., 2018). The gene discussed is CD8A; the disease is neoplasm.