The scRNA-seq data further disclosed that the four chemokines and their receptors were highly expressed in DCs, enhancing the antigen presentation in TME; the high CCL5 expression in CD8 T cells, NK cells, and certain TAM promoted inflammation; the tumor cells highly expressing CXCL9, CXCL10, and CXCL11 attracted the CD8 T cells, NK cells, and TAM, which eliminated tumor cells by perforating cell membrane, digesting through serine proteases and apoptosis via ligand binding (Lee et al., 2018). This evidence concerns the gene CCL5 and neoplasm.