Through the above studies, we found out a strongly positive correlation between four chemokines (CXCL9, CXCL10, CXCL11, and CCL5) and three kinds of immune cells (Macrophage M1, CD8, and CD4 T cells) in the immune phenotypes of HNSCC. The gene discussed is CCL5; the disease is head and neck squamous cell carcinoma.