As shown in previous studies, the VEGF-PIK3/AKT pathway activated by CCL5 promoted tumor metastasis by stimulating angiogenesis and ECM remodeling (Karnoub et al., 2007; Wang et al., 2012), and the robust expression of CXCL10 also enhanced gastric cancer invasion and metastasis by binding the receptor CXCR3A (Yang et al., 2016). Here, AKT1 is linked to gastric cancer.