These conditions—HBOC syndrome (associated with BRCA1 and BRCA2 genes), Lynch syndrome (LS) (associated with MLH1, MSH2, MSH6, and PMS2 genes), and FH (associated with APOB and LDLR genes)—are collectively identified as “Tier 1” conditions. This evidence concerns the gene MLH1 and Hereditary breast and ovarian cancer syndrome.