We found higher expression of TRAF5 and ZBP1 was associated with good survival (Figures 6I–J), However, higher expression in SLC25A5 predicted bad survival (Figure 6K); in addition, the quantitative real-time PCR assay showed SLC25A5 was up regulated in HNSCC cell line (Figure 6L), indicating this could be a carcinogenesis gene in necroptosis-related molecules. The gene discussed is ZBP1; the disease is head and neck squamous cell carcinoma.