S100A4 and osteosarcoma: Gao et al. (2016) demonstrated that CGB5 may induce tumor growth and vasculogenic mimicry formation via activation of the luteinizing hormone receptor signal pathway. Ren et al. (2015) found that RLN2 facilitates cell proliferation, migration, and invasiveness of osteosarcoma in vitro through the S100A4/MMP-9 signal pathway.