Notably, none of the Nex-Scrib−/− cKO mice suffered from microcephaly, and this was expected considering that the main characteristic of this cKO line is to bypass the negative impact of Scrib loss on proliferation and neurogenesis observed in the Emx1-Scrib−/− mutant mice (Ezan et al., 2021). The gene discussed is EMX1; the disease is microcephaly.