Scrib mutant Crc and myocardium-specific Scrib cKOs display ventricular septal defects and thinned myocardial walls that recapitulate cardiac features of VRJS patients (Phillips et al., 2007; Boczonadi et al., 2014) in line with a fetal case carrying SCRIB haploinsufficiency (Wells et al., 2016). The gene discussed is SCRIB; the disease is 8q24.3 microdeletion syndrome.