A role for SCRIB in the face, vertebrae, and digit development was suggested (Wells et al., 2016), and Scrib expression is increased in a craniosynostosis chick embryo model (Li et al., 2011) and also in mature osteoclast in vitro, hinting at a function in bone mass regulation (Orriss et al., 2018). Here, SCRIB is linked to craniosynostosis.