Moreover, in CRC, exon skipping in the 5’ coding region of the immune gene PD-L1 can generate splicing isoform b, which has a more significant inhibitory impact on T cells than the typical PD-L1 protein and may be a new biomarker for the efficacy of anti-PD-1/PD-L1 immunotherapy (16). Here, CD274 is linked to colorectal carcinoma.