AFP and hepatocellular carcinoma: However, for HCC patients with low AFP expression, whether or not with hepatitis virus infection, sEVs’ miRNAs are more indicative of being markers of HCC when they are expressed as miR-10b-5p+ miR-221-3p+ miR-223-3p and miR-10b-5p+ miR-221-3p+ miR-223-3p+ miR-21-5p (234).