The surface receptors of NK cells killer cell lectin like receptor K1 (KLRK1), also known as NKG2D, and DNAX accessory molecule-1 (DNAM-1), also known as CD226, are required for cell-mediated killing via binding to their ligands ribonucleic acid export-1 (RAE-1) and poliovirus receptor (PVR), respectively, both of which are expressed by MM cells (236, 237). The gene discussed is CD226; the disease is Miyoshi myopathy.