However, since cyclin D1 expression enhances MM cell adhesion to stromal cells and fibronectin, favors cell migration, and increases chemotaxis as well as inflammatory chemokine secretion, CFZ-mediated resistance was alleviated particularly in cyclin D1 expressing cells by the immunomodulatory drugs, which modify MM–TME interactions, such as CAM-DR (171). This evidence concerns the gene FN1 and Miyoshi myopathy.