Related work has shown that inhibition of the C-terminal transmembrane domain of MUC1 (MUC1-C) is synergistic with BTZ in downregulating p53-inducible regulator of glycolysis and apoptosis (TIGAR) expression, as well as in depleting NADPH and increasing ROS levels, leading to MM cell death (305). This evidence concerns the gene MUC1 and Miyoshi myopathy.