Myeloma cells interact with BMSCs via binding of very late antigen-4 (VLA-4), also known as α4β1 integrin, to vascular cell adhesion molecule 1 (VCAM1) or via binding of lymphocyte function associated-1 (LFA-1), also known as integrin subunit ß2, or Mucin 1 (MUC1, cell surface associated) to intercellular adhesion molecule 1 (ICAM-1) (46). This evidence concerns the gene ICAM1 and plasma cell myeloma.