While in MM this interaction activates nuclear factor kappa B (NFκB) signaling, a major driver of MM survival and proliferation (50), in BMSCs, it induces the activation of the mitogen-activated protein kinase (MAPK), Notch, and phosphoinositide 3-kinase (PI3K) pathways, which leads to the transcription and subsequent secretion of numerous cytokines (51). This evidence concerns the gene WNK2 and Miyoshi myopathy.