ILK-dependent signaling regulates basal and induced PD-L1 expression in the epithelial CRC cell lines and promotes resistance of CRC cells to immune cell killing activity in vitro. Accordingly, this pseudokinase is likely an important component of the immunosuppressive TME and may potentially be involved in the counterbalance between the anti-tumor immune response and inhibitory factors promoting immune evasion. The gene discussed is CD274; the disease is neoplasm.