After consulting the literature, we find that most of the genes that are positively related to MSLN are involved in cell adhesion and are related to tumor cell invasion and metastasis, such as CD81, CD151, MSLNL, SLC9A3R2, etc. And these genes are involved in related pathways such as innate immune system and class I MHC mediated antigen processing and presentation (31, 32). This evidence concerns the gene CD81 and neoplasm.