IFNG and neoplasm: Activated NK cells expressing CD16/IFNg/IL17 have a strong immune activator function (20, 21) that may induce plasticity changes in tumor-associated macrophages [TAMs/type 2 macrophages (M2)] toward the type 1 macrophage (M1) phenotype that may convert the tumor microenvironment toward a pro-inflammatory state and allow for active avoidance of thyroid cancer as described previously (13).