Interestingly, cancers such as colon and pancreatic cancers, which have the highest desmoplastic reaction by histopathology, exhibit only moderate 68Ga-FAPI uptake (SUVmax of 6–12), this may be due to the variability of cancer, i.e., cancer development is complex and FAP expression varies at different stages of stromal remodeling, a conjecture that requires large sample studies to verify (31, 70). The gene discussed is FAP; the disease is cancer.