CD8A and neoplasm: These data show that Imprime elicits 1) increased cytotoxic responses from innate immune cells, specifically NK cell-mediated tumor killing; 2) enhanced maturation and antigen presentation function of DCs; 3) innate immune reprogramming to repolarize the normally suppressive macrophages that dominate the tumor immune microenvironment; and 4) a robust infiltration of activated CD8 T cells in the tumor.