We next tested whether Imprime could foster this repolarization and drive T cell expansion in the presence of immunosuppressive cytokine/growth factor-containing TCM harvested from the culture of the human pancreatic cancer cell line BxPC-3, a cell line demonstrated to produce immunosuppressive cytokines such as VEGF and as such induce M2 polarization (Supplementary Figure 4B and (21–23)). The gene discussed is VEGFA; the disease is pancreatic neoplasm.