We then checked whether Imprime treatment alone would impart M1 characteristics to the tumor, and as shown in Figures 8B, Imprime treatment versus vehicle treatment upregulated several M1-related genes, such as Il12b, Tnfa, and Cxcl9/10/11, and downmodulated M2 genes, including Tgfb, Il10, Ccl22, Mrc1, Ym1, and Arg1. This evidence concerns the gene IL12B and neoplasm.