In mice treated with Imprime, a significantly higher percentage of CD8 T cells expressed both Ki67 and GrzB (Figure 6D), and when isolated and stimulated with anti-CD3/CD28 monoclonal Abs, exhibited enhanced proliferation and production of critical anti-tumor effector cytokines IFN-γ, IL-2, and TNF-α (Figure 6E). The gene discussed is CD28; the disease is neoplasm.