HIF1A and hepatocellular carcinoma: Under hypoxic conditions, transcription factor HIF1α can mediate the transcriptional activation of some genes related to glucose uptake, metabolism, and cell proliferation, such as MAPK1, VEGF, MDR1 (ABCB1), GLUT1, to facilitate the adaptive response of liver tumor cells to hypoxia, thereby increasing the therapeutic resistance of HCC to sorafinib (14).